Discover the signal
Screen extracts and molecular combinations in suitable cell models to find measurable biological activity.
Science / Technology + evidence
Activity first.
Precision follows.
Dinetic begins with a measured biological response. We identify the molecular system behind that response, rebuild it from defined components and evaluate each development layer separately. Fraktion8 is the first result of this research approach.
01 / BIOACTIVE RATIO TECHNOLOGY
The ratio is the technology.
Fraktion8 is a fixed combination of selected cannabinoids assembled from pure isolates. More than 100 combinations were screened to determine which components and proportions produced the strongest response in cell models. The selected system was then rebuilt without relying on a variable plant extract.
This creates a reproducible composition with the biological complexity of a molecular system.
02 / THE RESEARCH METHOD
From biological signal to usable technology.
The work does not end when activity is observed. Each stage resolves a different source of uncertainty before the system reaches a partner or product.
Resolve the system
Determine which selected molecules and proportions are responsible for the observed response.
Rebuild with precision
Assemble the system from pure isolates in a fixed ratio that can be reproduced from batch to batch.
Prepare the application
Integrate the active into a nanoemulsion and develop the technical path for topical formulation.
03 / Evidence, in context
A research programme.
An expanding evidence base.
Cell-based research and human-in-use evaluation inform the development of Fraktion8. The tested formulation, method and endpoint determine what a result can support.
Biological evaluation
01In vitro
Up to 4× the effect of pure CBD at the same dose inhibition of the NF-κB pathway, as well as TNF-a in a cell model at INRAE Montpellier, with cell viability maintained. A measurement in cells. It describes activity in a model, not an outcome in people.
Application evaluation
02Human-in-use
20 of 20 subjects showed measurably less redness, significantly improved skin barrier function and reduced transepidermal water loss in patients with sensitive skin. Dermatologically supervised in-use evaluation over four weeks, instrumental measurement.
Testing underway
03Fraktion8 + Nanoemulsion
Three endpoints in evaluation. Fraktion8 has been encapsulated in a nanoemulsion carrier to improve delivery and penetration of Fraktion8.
04 / Beyond the active
The system matters.
So does its delivery.
An active that stays on the surface of the skin is an active you paid for and did not use. The ratio decides what Fraktion8 does. The carrier decides whether it gets through the epidermis. That makes delivery a second piece of technology, not a formulation detail. Fraktion8 has been encapsulated in a nanoemulsion carrier. The droplets are extremely small: roughly a thousand would fit across the width of a single hair. Small enough to stay evenly suspended in the formula, and to cross the epidermis.
05 / THE PLATFORM AHEAD
Fraktion8 is the first proof of a broader method.
The same activity-led logic can be applied to other plants and molecular classes. The nanoemulsion work also creates a formulation route for further lipophilic actives. Dinetic's longer-term direction is to develop defined bioactive and delivery systems for skin and topical applications.
Future systems may investigate biological questions associated with disrupted or highly reactive skin. Every programme will require its own evidence, formulation work and regulatory path before an application or benefit is communicated.